This has come up recently when writing Windsor Interceptors and also methods that use reflection to walk my assemblies and automatically register components with my container. In these scenarios I end up with the concrete type in a variable of type Type, while the interface or base class I'm checking for is statically known. In the midst of my "where" clauses like "where type.IsGenericType && type.IsPublic" it's tempting to write "type.IsAssignableFrom(typeof(IMyInterface))", but this is, of course, incorrect. You have to reverse the order to get "typeof(IMyInterface).IsAssignableFrom(type)". There's a small amount of cognitive dissonance for me every time I have to do it.
What I'm really thinking is "make sure 'type' is an 'IMyInterface'. Why not make it so the API reflects that? Here's a little extension method that will let you write "where type.IsA<IMyInterface>()" instead. This reads a lot more naturally to me.
public static class TypeExtensions
public static bool IsA<T>(this Type type)